Search results for "cerebrospinal fluid [Biomarkers]"
showing 10 items of 20 documents
Spontaneous cerebrospinal fluid rhinorrhea: A clinical and anatomical study
2010
Objectives/Hypothesis: Spontaneous nasal cerebrospinal fluid (CSF) fistula represents a rare clinical entity. The possible etiology and the localization of the rhinorrhea remain an ongoing clinical challenge. The purpose of this study was to evaluate the localization of spontaneous CSF fistula and to correlate it with anatomical studies. Study Design: Retrospective clinical study, prospective anatomical study. Methods: Twenty-nine patients with spontaneous CSF rhinorrhea were retrospectively studied, 10 males and 19 females. Ages ranged from 10 to 92 years (mean, 50 years). In addition, 48 human skulls from newborns to adults were examined for the postnatal development of the anterior and m…
Antibiotic single-dose prophylaxis of shunt infections.
1989
Shunt infections after implantation or revision of a shunt for CSF drainage in hydrocephalic patients are serious complications. In view of their frequency, this study investigated the efficacy of prophylactic administration of a single dose of the antibiotic cefazedone in reducing in the post-operative infection rate. Fifty children of up to 14 years of age suffering from hydrocephalus of various etiologies were treated prophylactically and compared with a similar untreated group. The diagnosis of infection was based mainly on microbiological and clinical observations and investigations. Classical infection parameters were also recorded and evaluated, but played only a secondary role in es…
Early Diagnosis of Acanthamoeba Infection during Routine Cytological Examination of Cerebrospinal Fluid
2006
ABSTRACT Early identification of Acanthamoeba in cerebrospinal fluid is mandatory to prevent fatal granulomatous amebic encephalitis. In the case presented here amebic trophozoites were detected in a routine cerebrospinal fluid sample. The antibiotic treatment and the apparently low virulence of this isolate were responsible for the benign progression of the infection.
Rifampin-impregnated silicone catheters: a potential tool for prevention and treatment of CSF shunt infections.
2003
Background: Infection continues to be one of the major complications of cerebro-spinal fluid shunting procedures. Recent insights in the pathophysiological mechanism of these foreign body infections have elucidated the difficulty of achieving successful treatment without device removal. The development of a rifampin-impregnated silicone catheter yielded excellent results in infection prevention and treatment in vitro as well as in an animal model. Patients and Methods: Here, we describe the application of this device in two patients with a complicated course of shunt infection. Results: In one patient the rifampin-impregnated shunt system was implanted after external drainage to prevent fur…
New method of bone reconstruction designed for skull base surgery
2008
The direct endonasal or transoral transclival approaches to the skull base permit effective, minimally invasive surgery along the clivus. Developing long-term, effective techniques to prevent cerebrospinal fluid (CSF) leaks and their consequences (infection and delayed healing) remains a major challenge. In this study we describe a method of bone reconstruction newly developed by us, which uses a custom designed silicone plug for bone replacement after minimally invasive skull base surgery with a low incidence of postoperative CSF leaks. German Landrace pigs were used to test the efficiency of the new technique. Twelve craniotomies were performed in six pigs using a subtemporal approach and…
A stereotactic device for rabbits based on mandibular and cranial landmarks
2008
✓ The authors have developed a stereotactic device for use in rabbits that uses the plane at the base of the mandible combined with cranial sutures as an anatomical reference. The device was developed for a study designed to evaluate catheters for infection prophylaxis, and this required the implantation of silicone catheters along a reproducible trajectory through the lateral ventricle. Cadaver and atlas studies demonstrated consistent spatial relationships between intracranial structures and the surface plane on which the animals were resting during the surgery. This plane is formed by the 2 mandibular angles and the mandibular tip. The authors developed a stainless steel stereotactic dev…
A nonlinear biomechanical model for evaluation of cerebrospinal fluid shunt systems.
1994
In view of complications arising from physical properties of cerebrospinal fluid shunts, a biomechanical model of hydrocephalus was set up to study in vivo parameters that may influence their function. These include: intracranial pressure, compliance and pulses, intrathoracic, intra-abdominal, and subcutaneous pressures, and the effects of siphonage and repeated valve flushing. Each of these factors was studied separately upon shunt implantation in the model. Results of testing of a sample low-pressure valve with antisiphon device conformed with consumer information in regard to valve opening pressure and pressure flow measurements. No customer information, however, was supplied concerning …
Top-cited articles in cerebrospinal fluid leak (rhinorrhea and otorrhea) (1945–2018)
2021
Abstract Introduction: As scientific knowledge has grown in biomedicine, it has also become necessary to develop tools to manage and understand the body of evidence. In that sense, bibliometrics has become a consolidated discipline for analyzing scientific activity, enabling the characterization of a particular field or area of knowledge by means of the quantification of the bibliographic characteristics of scientific publications. Objective: The objective of this study was to determine the most frequently cited articles in the field of cerebrospinal fluid rhinorrhea and otorrhea. Methods: The searches took place on the Clarivate Analytics Web of Science platform, which includes the MEDLINE…
Letter: Cerebrospinal Fluid Shunting Improves Long-Term Quality of Life in Idiopathic Normal Pressure Hydrocephalus.
2020
Manejo de las otolicuorreas
2013
Introduction: Cerebrospinal fluid otorrhea results from an abnormal communication between the subarachnoid space and tympanomastoid compartment; most of them are of traumatic aetiology. They have clinical interest due to the potential risk of meningitis, directly related to the aetiology. Our aim was to show our experience in the management of this process. Methods: A total of 17 patients diagnosed and treated for cerebrospinal fluid otorrhea from 2003 to 2011.